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         DIAGNOSIS AND TREATMENT GUIDLINES
    ADVANCED TOPICS IN LYME DISEASE
    Guidelines by JOSEPH J. BURRASCANO JR., M.D.
    Download PDF File
    *************
    ILADS Evidence-based Lyme Treatment Guidelines
    International Lyme and Associated Diseases Society
    Download PDF File

         Translate

         Obituaries
    ·Remembering Leslie Wermers. Six years ago today2014-11-02 00:00:00
    ·Remembering Leslie Wermers. Five years ago2013-10-28 18:35:31
    ·Remembering Leslie Wermers. One year ago today.2009-11-02 20:10:50
    ·Lyme disease patients mourn passing of well known doctor2009-07-01 04:00:00
    ·All she lost: My sister's battle with Lyme disease2009-05-19 04:00:00
    ·Laura Treanor, 19, Lyme disease not ruled as cause of death2009-05-07 04:00:00
    ·Lila Star Smith Harms, 25, dies from complications of Lyme disease2009-05-05 04:00:00
    ·Lyme Disease Patients Loses a Hero and Friend2008-11-16 19:57:38
    ·Nancy L. (Scully) Strayer: March 20, 1946 - March 12, 20082008-04-12 04:00:00
    ·Bite from tick on holiday led to death leap2008-04-11 06:49:39
    ·Rugby great, Mike Gregory, loses his battle with Lyme disease2007-11-24 23:51:00
    ·Missouri teen, 15, dies from Ehrlichiosis2007-09-04 04:00:00
    ·Steven F. Wells, 45, dies after battle with Lyme disease and ALS2007-08-14 07:03:39
    ·Bruno C. Malvezzi2007-07-31 21:06:47
    ·In loving memory of Dr. Edward McNeil2007-07-24 19:45:00
    ·Lyme disease is a growing problem, Britteny Gallgher, Kansas City, MO2007-05-24 04:10:00
    ·Lyme Disease Skyrockets In Maryland2007-05-23 04:00:00
    ·C. Peter Thomas, 46; Sound Engineer2007-05-21 04:00:00
    ·Jimmy Duarte, gifted musician, charismatic islander, dies at 702007-05-17 15:12:03
    ·Obituary: Lyme Disease Advocate Karen Johnson ''Rose'' Rose, 1947 - 20072007-04-30 22:50:17
    ·BETH'S QUEST: Family crusades against Lyme disease2007-04-29 04:00:00
    ·Tick kit distribution aimed at heading off Lyme disease2007-04-28 12:40:00
    ·Letter to the Editor: In Memory of Lyme Advocate ''Rose''2007-04-26 11:00:03
    ·Lyme Advocate ''Rose'' Succumbs to Lyme Disease2007-04-19 18:25:19
    ·Body of Missing Woman with Lyme Disease Found2007-04-14 21:46:32
    ·Michael Coers won Pulitzer Prize2007-03-21 10:00:43
    ·E STREETER IN LYME 'SUICIDE'2007-03-19 12:33:30
    ·Lost to Lyme Lyme disease facts2007-03-19 04:00:00
    ·Musician remembered as battler against Lyme disease2007-03-19 04:05:00
    ·Maine Musician Bill Chinnock Dies2007-03-08 13:45:18
    ·Obituary - Eric von Schmidt - Singer and painter was in Dylan's circle2007-02-27 11:00:00
    ·JAMES P. KOCH2007-02-22 00:53:49
    ·Andrew Spielman, 76, Expert on Insect-Borne Diseases, Dies2006-12-26 04:00:00
    ·Martin Frank Dumke2006-11-29 04:00:00
    ·Bill Reynolds: For QB Coen, tragedy lies beneath the surface2006-10-29 04:05:00
    ·Coen plays on without No. 1 fan2006-10-17 04:00:00
    ·Librarian was dedicated to students, family2006-09-19 17:02:58
    ·TORMENT OF BRAIN BUG PROF - Alasdair Crockett2006-09-19 13:43:35
    ·Widow of Lyme disease victim appeals for help2006-09-18 22:44:57
    ·Professor commits suicide after catching dementia from tick bite2006-09-17 22:17:12
    ·Tick talk: Family blames member's death on tickborne illness2006-08-21 04:00:00
    ·Death of York PA area doctor due to Lyme and ALS2006-04-29 20:40:02
    ·Emmy-winner Scott Brazil dies of ALS and Lyme disease at 502006-04-22 11:37:59
    ·Kym Cooper- Dead Woman's Own Letter Tells Her Lyme Disease Story2006-02-05 14:08:53
    ·Kym Cooper - Worn down by Lyme2006-01-22 01:56:26
    ·Kym Cooper, 1968-2006, After long battle with Lyme disease2006-01-19 13:51:02
    ·Tribe leader Francis mourned2006-01-14 18:22:58
    ·Easton mourns former selectman after fatal accident2005-12-17 13:04:17
    ·Educator, union leader dies from complications of Lyme disease2005-12-08 09:25:32
    ·'A TERRIBLE WAY TO GO'2005-10-22 14:39:56
    ·Leo Bogart, R.I.P. (1921-2005)2005-10-21 15:55:28
    ·Leo Bogart, 84, Sociologist Who Studied Role of Media in Culture, Is Dead2005-10-21 15:46:44
    ·Passages: Pat Pepper2005-10-10 01:11:11
    ·Man loses battle with Lyme disease2005-10-09 10:37:43

    [ Read Obituaries ]

         U.S. Army, 1983-1996 Lyme Disease Risk Assessments
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     Lyme vaccine number 2- Vaccine history Rheumatic Fever

    Opinion / Editorial
    Lymeblog News
    February 27. 2015
    Lexington, KY USA
    By Alan B. MacDonald MD, FCAP, FASCP
    Source: LymenetEurope

    Hopes of success with a novel vaccine for Lyme borreliosis should be viewed
    Watch Dr. MacDonald's video "Borrelia spirochaetes Detected in autopsy Alzheimer Brain"
    through the lens of history.

    Vaccines which actually provide protection against a target infection are slow to perfect, Jenner and the Cowpox/Smallpox model not-withstanding.

    Rheumatic Fever, is no longer a significant public health problem in the developed world. Rheumatic Fever and allied post streptococcal illnesses continue to be major problems in the undeveloped countries, particularly African countries.

    The historical discussion of attempts for a Vaccine to prevent Rheumatic Fever is pertinent to the hopes for the development of a Vaccine for Lyme borreliosis: Herein a synopsis of the frustrations with a Rheumatic Fever vaccine quoted from the Lancet:

    Posted by Editor on Friday, February 27 @ 14:32:10 EST (270 reads)
    Read More... | 4388 bytes more | comments? | Score: 0

     People don't understand lyme disease

    Opinion / Editorial
    LymeBlog News
    Lexington, KY USA
    June 1, 2014
    by Julie Newland

    Julie Newland
    Julie Newland
    Delaware, OH: I hesitated writing this. Then I realized I must. Many of you might know me or know of me. Marion (Ohio) was my home for my life. I was very active there in food drives and politics. I tried to help my town. I was energetic, happy and never still. Then one day, it began to change.

    Imagine losing your balance, getting vision problems, severe joint and muscle pain, stiffness, and having tremors and twitching like mad. You also lose a lot of cognitive abilities. I went from ballroom dancing to being home and needing help within a year. I was at the top hospitals in Ohio. I saw so many neurologists, cardiologists and other doctors. No one had an answer. They had ideas, but none proved to ...

    Posted by Editor on Sunday, June 01 @ 22:21:39 EDT (1166 reads)
    Read More... | 7055 bytes more | comments? | Score: 0

     Opinion / Editorial: Distinct pattern of cognitive impairment noted in study of Lyme patients

    Opinion / Editorial
    Distinct Pattern of Cognitive Impairment Noted in Study of Lyme Patients Marian Rissenberg PhD & Susan Chambers MD, The Lyme Times, Vol. 20, Jan-Mar 1998, pp. 29-32
    From: Melissa Kaplan'sChronic Neuroimmune Diseases
    Information on CFS, FM, MCS, Lyme Disease, Thyroid, and more...


    Synopsis: This study demonstrates that for the majority of chronic Lyme patients with cognitive complaints, there is in fact a measurable and significant decline in intellectual acuity. The nature and severity of the cognitive impairment is such that it interferes with all aspects of normal functioning: employment, home, marriage, social interactions, and general emotional well-being.


    I. Cognitive Characteristics of Chronic Lyme Encephalopathy

    On the basis of both a formal neuropsychological study of 49 patients (APA 5/96) and on clinical observation and comprehensive neuropsychological examination of well over 100 patients, a distinct pattern of cognitive impairment occurring chronic Lyme disease can be described. These patients consistently demonstrate deficits in directed, sustained and divided attention, planning and organization of responses, temporal ordering, verbal fluency, abstract reasoning, speed of processing, and motor programming. The overall pattern of intellectual impairment is not unlike that seen with diffuse brain injury, and it most often results in some degree of work-related disability.

    Although performance is impaired on measures of cognitive functions associated with specific brain regions -- receptive and expressive language, visuospatial problem solving and memory -- the quality of performance is not suggestive of focal lesions in these areas. Rather, deficits are secondary to impairment of higher level integrative functions, likely mediated by complex neuronal systems. Specifically, the receptive language deficit is secondary to impaired auditory tracking and slowing of mental processing. The expressive language deficit is secondary to impaired word retrieval and response planning, The visuospatial problem solving deficit is secondary to impairment of mental flexibility, conceptualization and the ability to compare and contrast necessary in decision making. Finally, deficits on test of memory function are most often secondary to impairment of the encoding or initial processing of information, which depends on attention, and the retrieval of stored information. The storage of new information, or memory per se, is rarely impaired.

    This pattern suggests that cognitive dysfunction in chronic Lyme, while expressed variably across individual patients, results from a common factor -- the breakdown of diffusely represented processes involving both integration and activation, and impacting primarily on attention and reasoning. The fluctuation of impairment over short periods of time suggest that a physiologic rather than a structural mechanism is responsible.

    II. Neuropsychological deficits in chronic Lyme disease
    (A study presented at the annual meeting of The American Psychiatric Association , May 1996)

    The neuro-psychological characteristics of 49 patients with Lyme disease were examined. The study set out to answer three

    Posted by Editor on Thursday, January 24 @ 11:49:06 EST (3241 reads)
    Read More... | 20188 bytes more | comments? | Opinion / Editorial | Score: 5

     Opinion / Editorial: Did Adam Lanza Have Lyme Disease?

    Opinion / Editorial
    A Tick-ing Time Bomb?
    Did Adam Lanza Have Lyme Disease?
    by JESSICA BERNSTEIN

    As the nation has been questioning how Adam Lanza could have committed such an unfathomable act, mental health issues have been at the forefront of the discussion. However, knowing that Newtown is located in a highly Lyme-endemic area, many in the Lyme community recognize that neurological lyme disease could be part of the answer to what led to the Connecticut shooting.

    Although most people or animals with Lyme or other tick-borne diseases are not violent, a small percentage have demonstrated violent behavior. Many may remember the chimpanzee named Travis who attacked the woman and tore off her face. That chimpanzee had Lyme disease and lived in Connecticut.

    Psychiatrist Robert Bransfield, M.D. estimates that aggressive behavior has been a significant issue for ...

    Posted by Editor on Saturday, January 12 @ 09:29:44 EST (2929 reads)
    Read More... | 9525 bytes more | comments? | Opinion / Editorial | Score: 0

     Report on the IOM Meeting Regarding Lyme Disease

    Opinion / Editorial
    “Medical progress should no longer be impeded by the polarizing controversy that has characterized Lyme disease research in the past. The dialogue must continue and encourage mutually respectful collaboration across scientific disciplines and among researchers, clinicians and patients, even when view points differ, if we are to make progress.”
    (Gregg Skall, Womble Carlyle Sandridge & Rice, PLLC)


    Report on the IOM Meeting Regarding Lyme Disease

    LymeBlog News
    Lexington, KY USA
    From: National Capital Lyme & Tick-Borne Disease Association
    www.natcaplyme.org
    natcaplyme@natcaplyme.org
    Phone & fax: 703-821-8833

    Washington, DC – Thursday, April 21, 2011.  The Institute of Medicine (IOM) released their report on April 20, 2011, on “The Critical Needs and Gaps in Understanding Prevention, Amelioration and Resolution of Lyme and Other Tick-Borne Diseases.” The report confirmed what Lyme patients have known for years – that Lyme disease is a serious illness, and significant gaps remain in our understanding of the disease.

    At the request of the National Institute of Allergy and Infectious Diseases (NIAID), the IOM was entrusted to plan and hold a two-day workshop to assess the state of the science of Lyme and other tick-borne diseases.  A committee was formed, which provided a forum for broad scientific and public input, and produced a summary report on the critical needs and gaps in research.

    Although we share the concern with many in the Lyme community that treatment was not included in this workshop, we are pleased that other critical themes were addressed. The National Capital Lyme Disease Association (NatCapLyme) would like to thank the IOM for completing this arduous task with integrity within the guidelines they were charged to respect.

    Pamela Weintraub’s powerful presentation at the IOM workshop last October made a notable impression on the IOM Committee.  In its preface, the IOM Committee wrote: “Pamela Weintraub spoke eloquently about her personal experience and her family’s challenges with Lyme Disease.” Echoing Pamela Weintraub’s call for research, the IOM report states that “a new environment of trust and a better environment for more constructive dialogue [is required] to help focus research needs and achieve better outcomes.”

    We commend the IOM for so effectively establishing the convergence of science with real-life situations and highlighting both the need for more scientific knowledge and the serious societal challenges that need to be addressed. 

    Importantly, the IOM Committee noted that “the burden of disease is a growing concern.” The Committee recognized that “tick-borne diseases (TBDs) represent some of the world’s most rapidly expanding arthropod-borne infectious diseases, yet significant gaps remain in our understanding and knowledge about them.”  Some of the themes discussed in the IOM report suggesting greater emphasis and more research are:

          ·  A national integrated research plan for advancing the science on tick-borne diseases;

          ·  A long-term study of Lyme disease and other TBD patients; Educational programs for the public;

          ·  The current status of diagnostic tests and biomarkers for tick-borne diseases;

          ·  Biorepositories for tick-borne diseases; Biological understanding of persistent symptoms;

          ·  The impact of coinfection in severity of human TBDs;

          ·  The role of immune response to tick-borne infection and its effect on bacterial load and disease manifestations;

          ·  Animal models that explore mechanisms of pathogen persistence following antibiotic treatment.

    A diverse group of scientists and physicians with expertise in tick-borne infections discussed a breadth of scientific topics. Some profound insights shared by several of these presenters include:

          ·  “Science is not belief, but the will to find out” (Benjamin J. Luft, M.D.)

          ·  “Everyone is studying the early stage of this infection, no one is studying the persistent phase of this infection.”  (Stephen Barthold, D.V.M., Ph.D.)

          ·  “You do not require an antibody response to develop this disease”  (Janis J.Weis, Ph.D.)

          ·  “Treat the patient, not the test”  (Juan Olano, M.D.)

          ·  “[For the child] long-term effects last 50-70 years”  (Richard F. Jacobs, M.D.)

          ·  “…the poor understanding of the true incidence and geographical distribution…I don’t think we have a clue”  (Richard F. Jacobs, M.D.)

          ·  “How can you say, ‘I’ve treated you for four weeks and therefore you no longer have Lyme disease.’ The fact is, we don’t know!” (Sam T. Donta, M.D.)

          ·  “Under-powered studies which purport to demonstrate universal efficacy need to be viewed with circumspection”  (Sam T. Donta, M.D.)

          ·  “All that shouting drowns out all the complexity and the nuance and the work that needs to be done”  (Pamela Weintraub, senior editor at Discover magazine, and author of Cure Unknown: Inside the Lyme Epidemic)

    In addition to thanking all the presenters, we want to express our gratitude to the Lyme community for supporting our effort to see this workshop through.  The thousands of Lyme patients who responded to our surveys and allowed their stories to be shared in “The Human Dimension of Lyme and Other Tick-Borne Diseases: The Patient’s Perspective,” the NatCapLyme paper commissioned by the IOM, provided a valuable contribution to the IOM workshop and report.http://www.iom.edu/Reports/2011/Critical-Needs-and-Gaps-in-Understanding-Prevention-Amelioration-and-Resolution-of-Lyme-and-Other-Tick-Borne-Diseases.aspx (p. A-67)

    We strongly urge each of you to continue the process that IOM initiated by reading the IOM report so that you can extract from these works what is beneficial to your specific case in your quest to achieve wellness and to overcome the negative effects of Lyme disease. http://www.iom.edu/Reports/2011/Critical-Needs-and-Gaps-in-Understanding-Prevention-Amelioration-and-Resolution-of-Lyme-and-Other-Tick-Borne-Diseases.aspx

    The IOM workshop brings us another step closer to improving the lives of Lyme patients and their families who have been profoundly impacted by tick-borne infections, and who have been caught in the crossfire of opposing views for such a long time.  The next logical step is collaboration between all stake holders to fill in the gaps uncovered in this workshop concerning diagnosis, addressing the topic of treatment, and the need for a consistency of language in discussing Lyme disease. “Medical progress should no longer be impeded by the polarizing controversy that has characterized Lyme disease research in the past. The dialogue must continue and encourage mutually respectful collaboration across scientific disciplines and among researchers, clinicians and patients, even when view points differ, if we are to make progress.” (Gregg Skall, Womble Carlyle Sandridge & Rice, PLLC)

    We implore Congress to fund and the IOM to convene a second workshop that would address research needs for effective treatment for persistent Lyme disease. 

    National Capital Lyme & Tick-Borne Disease Association

    P.O. Box 8211 · McLean VA 22106-8211 · Phone & Fax 703-821-8822
    NatCapLyme@natcaplyme.org · http://www.natcaplyme.org


    Posted by Editor on Friday, April 22 @ 22:11:45 EDT (3444 reads)
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         U.S. Army, 1983-1996 Lyme Disease Risk Assessments
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